redox-responsive polymer nanoparticles  (BioMimetic Therapeutics)

Journal: Pharmaceutics

Article Title: Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

doi: 10.3390/pharmaceutics15071821

Figure Lengend Snippet: The unique advantages of biomimetic cell-derived nanoparticles. By Figdraw.

Article Snippet: Activated neutrophils membrane , Redox-responsive polymer nanoparticles , Good biocompatibility and biodegradability, low passive targeting efficiency, rapid clearance by macrophages , DOX , 4T1 cells, classic tumor model , The biomimetic nanoparticle platform could prevent the recruitment and functions of MDSCs, thereby inhibiting tumor recurrence and metastasis. , [ ] .

Techniques: Derivative Assay

Journal: Pharmaceutics

Article Title: Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

doi: 10.3390/pharmaceutics15071821

Figure Lengend Snippet: The fabrication of biomimetic cell-derived nanoparticles. By Figdraw.

Article Snippet: Activated neutrophils membrane , Redox-responsive polymer nanoparticles , Good biocompatibility and biodegradability, low passive targeting efficiency, rapid clearance by macrophages , DOX , 4T1 cells, classic tumor model , The biomimetic nanoparticle platform could prevent the recruitment and functions of MDSCs, thereby inhibiting tumor recurrence and metastasis. , [ ] .

Techniques: Derivative Assay

Journal: Pharmaceutics

Article Title: Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

doi: 10.3390/pharmaceutics15071821

Figure Lengend Snippet: Application of biomimetic cell-derived nanoparticles in ICIs.

Article Snippet: Activated neutrophils membrane , Redox-responsive polymer nanoparticles , Good biocompatibility and biodegradability, low passive targeting efficiency, rapid clearance by macrophages , DOX , 4T1 cells, classic tumor model , The biomimetic nanoparticle platform could prevent the recruitment and functions of MDSCs, thereby inhibiting tumor recurrence and metastasis. , [ ] .

Techniques: Membrane, Encapsulation, Expressing, Amplification, Drug discovery, Blocking Assay, Liposomes, Knock-Out

Journal: Pharmaceutics

Article Title: Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

doi: 10.3390/pharmaceutics15071821

Figure Lengend Snippet: Application of biomimetic cell-derived nanoparticles in ACT.

Article Snippet: Activated neutrophils membrane , Redox-responsive polymer nanoparticles , Good biocompatibility and biodegradability, low passive targeting efficiency, rapid clearance by macrophages , DOX , 4T1 cells, classic tumor model , The biomimetic nanoparticle platform could prevent the recruitment and functions of MDSCs, thereby inhibiting tumor recurrence and metastasis. , [ ] .

Techniques: Membrane, Produced, Amplification, Activation Assay, Modification, Activity Assay

Journal: Pharmaceutics

Article Title: Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

doi: 10.3390/pharmaceutics15071821

Figure Lengend Snippet: Application of biomimetic cell-derived nanoparticles in cancer vaccines.

Article Snippet: Activated neutrophils membrane , Redox-responsive polymer nanoparticles , Good biocompatibility and biodegradability, low passive targeting efficiency, rapid clearance by macrophages , DOX , 4T1 cells, classic tumor model , The biomimetic nanoparticle platform could prevent the recruitment and functions of MDSCs, thereby inhibiting tumor recurrence and metastasis. , [ ] .

Techniques: Vaccines, Membrane, Adjuvant, Immunopeptidomics, Infection, Activation Assay, Transgenic Assay, Expressing

Journal: Pharmaceutics

Article Title: Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

doi: 10.3390/pharmaceutics15071821

Figure Lengend Snippet: The immunosuppressive tumor microenvironment (ITME) and biomimetic cell-derived nanoparticles for reversing the ITME. By Figdraw.

Article Snippet: Activated neutrophils membrane , Redox-responsive polymer nanoparticles , Good biocompatibility and biodegradability, low passive targeting efficiency, rapid clearance by macrophages , DOX , 4T1 cells, classic tumor model , The biomimetic nanoparticle platform could prevent the recruitment and functions of MDSCs, thereby inhibiting tumor recurrence and metastasis. , [ ] .

Techniques: Derivative Assay

Journal: Pharmaceutics

Article Title: Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

doi: 10.3390/pharmaceutics15071821

Figure Lengend Snippet: Application of biomimetic cell-derived nanoparticles in modulating the ITME.

Article Snippet: Activated neutrophils membrane , Redox-responsive polymer nanoparticles , Good biocompatibility and biodegradability, low passive targeting efficiency, rapid clearance by macrophages , DOX , 4T1 cells, classic tumor model , The biomimetic nanoparticle platform could prevent the recruitment and functions of MDSCs, thereby inhibiting tumor recurrence and metastasis. , [ ] .

Techniques: Membrane, Concentration Assay, Activation Assay, Expressing, DNA Methylation Assay, Polymer, Blocking Assay, Generated, Irradiation

Journal: Pharmaceutics

Article Title: Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

doi: 10.3390/pharmaceutics15071821

Figure Lengend Snippet: PDA/GNS@aPD-L1 nanoparticles for cancer immunotherapy by combining PTT with PD-1/PD-L1 blockade. ( a ) The preparation of PDA/GNS@aPD-L1. ( b ) PDA/GNS@aPD-L1 binding capability for PD-L1-expressing cells. ( c ) PTT effects of PDA/GNS@aPD-L1. Scale bar: 100 μm. ( d ) Anti-cancer effect of PDA/GNS@aPD-L1 in primary tumor. ( e , f ) PDA/GNS@aPD-L1 reversed the ITME by decreasing the number of Treg and MDSC cells at the tumor site. ( g ) Anti-cancer effect of PDA/GNS@aPD-L1 in distal tumor. G1, PBS group; G2, PDA-GNS + NIR group; G3, PDA/GNS@Free NPs group; G4, PDA/GNS@aPD-L1 NPs group; G5, aPD-L1 mAb group; G6, aPD-L1 NVs + PDA-GNS + NIR group; G7, aPD-L1 mAb + PDA-GNS + NIR group; G8, PDA/GNS@aPD-L1 NPs + NIR group. ns: no significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001. Reproduced under the terms of the CC BY-NC-ND license .

Article Snippet: Activated neutrophils membrane , Redox-responsive polymer nanoparticles , Good biocompatibility and biodegradability, low passive targeting efficiency, rapid clearance by macrophages , DOX , 4T1 cells, classic tumor model , The biomimetic nanoparticle platform could prevent the recruitment and functions of MDSCs, thereby inhibiting tumor recurrence and metastasis. , [ ] .

Techniques: Binding Assay, Expressing

Journal: Pharmaceutics

Article Title: Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

doi: 10.3390/pharmaceutics15071821

Figure Lengend Snippet: Application of biomimetic cell-derived nanoparticles in combination therapy.

Article Snippet: Activated neutrophils membrane , Redox-responsive polymer nanoparticles , Good biocompatibility and biodegradability, low passive targeting efficiency, rapid clearance by macrophages , DOX , 4T1 cells, classic tumor model , The biomimetic nanoparticle platform could prevent the recruitment and functions of MDSCs, thereby inhibiting tumor recurrence and metastasis. , [ ] .

Techniques: Membrane, shRNA, Modification, Expressing, Liposomes

Journal: Pharmaceutics

Article Title: Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

doi: 10.3390/pharmaceutics15071821

Figure Lengend Snippet: Biomimetic cell-derived nanoparticles for cancer bio-imaging, prevention, diagnosis, and treatment. By Figdraw.

Article Snippet: Activated neutrophils membrane , Redox-responsive polymer nanoparticles , Good biocompatibility and biodegradability, low passive targeting efficiency, rapid clearance by macrophages , DOX , 4T1 cells, classic tumor model , The biomimetic nanoparticle platform could prevent the recruitment and functions of MDSCs, thereby inhibiting tumor recurrence and metastasis. , [ ] .

Techniques: Derivative Assay, Imaging, Biomarker Discovery